Antigen-presenting cells, such as dendritic cells, form an intimate contact with T cells to transfer antigenic signals (1), co-stimulatory signals (2) and paracrine cytokine signals (3). In this so-called immunological synapse, a variety of immunomodulating molecules aggregate to drive signaling that leads to activation and proliferation of immune effector cells such as T cells and NK cells. We developed unique semi-flexible polymers decorated with a variety of immunomodulating molecules to mimic natural antigen presenting cells. These ‘immunofilaments’ are designed to specifically activate and expand immune cells such as antigen specific cytotoxic T cells, CAR-T cells, or NK cells. Our immunofilaments not only effectively expand immune cells ex vivo, but can also drive expansion of immune cells in vivo, resulting in inhibition of tumor growth or metastasis.
For further reading:|
‘Dictating Phenotype, Function, and Fate of Human T Cells with Co-Stimulatory Antibodies Presented by Filamentous Immune Cell Mimics’
Schluck M, Eggermont LJ, Weiden J, Popelier C, Weiss L, Pilzecker B, Kolder S, Heinemans A, Rodriguez Mogeda C, Verdoes M, Figdor CG and Hammink R.
Adv. Therap. 2022, DOI 2200019
‘Semiflexible Immunobrushes Induce Enhanced T Cell Activation and Expansion’
Hammink R, Weiden J, Voerman D, Popelier C, Eggermont LJ, Schluck M, Figdor CG and Verdoes M.
ACS Appl. Mater. Interfaces, 2021, 13, 14, 16007.
‘Synthetic Semiflexible and Bioactive Brushes’
Voerman D, Schluck M, Weiden J, Joosten B, Eggermont LJ, van den Eijnde T, Ignacio B, Cambi A, Figdor CG, Kouwer PHJ, Verdoes M, Hammink R. and Rowan AE.
Biomacromolecules, 2019, 20, 2587.
‘Cytokine-functionalized Synthetic Dendritic Cells for T Cell Targeted Immunotherapies’
Eggermont LJ, Hammink R, Blank KG, Rowan AE, Tel J, Figdor CG.
Adv. Therap, 2018, DOI1800021.
‘Affinity-Based Purification of Polyisocyanopeptide Bioconjugates’
Hammink R, Eggermont LJ, Zisis T, Tel J, Figdor CG, Rowan AE, Blank KG.
Bioconj. Chem., 2017, 28 (10), 2560.
‘Controlling T-cell activation with synthetic dendritic cells using the multivalency effect’
Hammink, R, Mandal, S, Eggermont, L, Nooteboom, M, Willems, P, Tel, J, Figdor, C. G, Blank, K. G. Rowan, A. E.
ACS Omega, 2017, 2 (3), 937.
‘Polymer-Based Synthetic Dendritic Cells for Tailoring Robust and Multifunctional T Cell Responses’
Mandal S, Hammink R, Tel J, Eksteen-Akeroyd Z. H, Rowan A. E, Blank K, Figdor C. G.
ACS Chem. Biol. 2015, 10 (2), 485.
‘Therapeutic nanoworms: towards novel synthetic dendritic cells for immunotherapy’
Mandal S, Eksteen-Akeroyd Z. H, Jacobs M. J, Hammink R, Koepf M, Lambeck A. J, van Hest J. C. M, Wilson C. J, Blank K, Figdor C. G, Rowan A. E.
Chem. Sci. 2013, 4 (11), 4168.